Gastrointestinal symptoms occur frequently among people with diabetes mellitus and are associated with considerable morbidity. Enteropathy, or large bowel dysfunction,includes constipation, diarrhea and fecal incontinence, and is particularly disturbing for many patients. The pathogenesis of diabetic enteropathy is complex, primarily related to gastrointestinal autonomic dysfunction and etiologically associated with chronic
A 29-year-old woman, with 15 years of poorly controlled type 1 diabetes and established diabetic autonomic diarrhoea, presented with worsening diarrhoea and diabetic ketoacidosis. Frequency of bowel opening was up to 40 times per 24 hours. Octreotide was started, rapidly decreasing bowel motion frequency. Due to previous intolerable side effects