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A model of translational research for diabetes prevention in low and middle-income countries: The Diabetes Community Lifestyle Improvement Program (D-CLIP) trial
- Item type: Scientific article
- Country: India
- Language: English
- Author: Weber MB, Ranjani H, Meyers GC, Mohan V, Narayan KMV
- Target audience: All health professionals
- Publication Date: Feb, 2011
- http://www.primary-care-diabetes.com/article/S1751-9918%2811%2900031-3/abstract
Aims
The Diabetes Community Lifestyle Improvement Program (D-CLIP) aims to implement and evaluate in a controlled, randomized trial the effectiveness, cost-effectiveness, and sustainability of a culturally appropriate, low-cost, and sustainable lifestyle intervention for the prevention of type 2 diabetes mellitus in India.
Methods
D-CLIP, a translational research project adapted from the methods and curriculum developed and tested for efficacy in the Diabetes Prevention Program, utilizes innovated methods (a step-wise model of diabetes prevention with lifestyle and metformin added when needed; inclusion of individuals with isolated glucose tolerance, impaired fasting glucose, and both; classes team-taught by professionals and trained community educators) with the goals of increasing diabetes prevention, community acceptability, and long-term dissemination and sustainability of the program. The study outcomes are: diabetes incidence (primary measure of effectiveness), cost-effectiveness, changes in anthropometric measures, plasma lipids, blood pressure, blood glucose, and HbA1c, Program acceptability and sustainability will be assessed using a mixed methods approach.
Conclusion
D-CLIP, a low-cost, community-based, research program, addresses the key components of translational research and can be used as a model for prevention of chronic diseases in other low and middle-income country settings (clinicaltrials.gov number, NCT01283308)
By Lorenzo
May 06, 2015
12:09